Vibration of tubes arrays is a matter of safety assessments of nuclear reactor cores or steam generators. Such systems count up thousands of slender-bodies immersed in viscous flow, involving multi-physics mechanisms caused by nonlinear dynamic interactions between the fluid and the solid materials. Direct numerical simulations for predicting these phenomena could derive from continuum mechanics, but require expensive computing resources. Therefore, one alternative to the costly micro-scale simulations consists in describing the interstitial fluid dynamics at the same scale as the structures one. Such approach rely on homogenization techniques intended to model mechanics of multi-phase systems. Homogenization results in coupled governing equations for the fluid and solid dynamics, whose solution provides individual tubes displacements and average fluid fields for each periodic unit cell. An hydrodynamic force term arises from the formulation within this set of homogenized equations: it depends on the micro-scale flow in the vicinity of a given tube-wall, but needs to be estimated as a function of the macro-scale fields in order to close the homogenized problem. The fluid force estimation relies on numerical micro-scale solutions of fluid-solid interactions over a tube array of small size. The multi-scale model is assessed for arrays made up of hundreds tubes, and is compared with solutions coming from the numerical micro-scale simulations. The macro-scale solution reproduces with good agreement the averaged solution of the micro-scale simulation, indicating that the homogenization method and the hydrodynamic force closure are suitable for such tube array configurations.