Thèse soutenue

FR
Accès à la thèse
Auteur / Autrice : Selma Čorovič
Direction : Lluis Maria MirDamijan Miklavčič
Type : Thèse de doctorat
Discipline(s) : Pharmacotechnie et physicochimie
Date : Soutenance en 2010
Etablissement(s) : Paris 11
Partenaire(s) de recherche : autre partenaire : Université de Paris-Sud. Faculté de pharmacie (Châtenay-Malabry, Hauts-de-Seine)

Résumé

FR  |  
EN

In vivo electroporation is used as an effective and safe tool for administration of a variety of extracellular agents such as chemotherapeutic drugs (e. G. Bleomycin), DNA or other molecules, which in normal conditions do not cross the cell membrane, into many different target tissue cells. The main focus of the present doctoral theses is the analysis of in vivo electroporation and corresponding local electric field distribution used in electrochemotherapy and electroporation based gene therapy and vaccination. The aims of this doctoral thesis cover three important issues in the development of electroporation based technologies and treatments: development of realistic numerical models of different tissues (i. E. Muscle, tumor and skin) and calculations and visualization of local electric field distribution in the models; validation of the realistic numerical models by in vivo experiments and development of a web-based interactive e-learning application on electroporation of cells and tissues and on electroporation based therapies and treatments. (e. G. Clinical electrochemotherapy of tumors and gene electrotransfer).