Thèse de doctorat en Vie-Agro-Santé
Sous la direction de Bernard Jegou.
Thèses en préparation à Rennes 1 , dans le cadre de Ecole doctorale Vie-Agro-Santé (Rennes) depuis le 09-10-2012 .
Since the early 50’s, paracetamol has an excellent reputation, which is why it is the most widely used analgesic in the world. However, several epidemiological studies have enabled us to correlate the consumption of paracetamol and / or anti-inflammatory drugs (NSAIDs) during pregnancy with the incidence of severe alterations to the development of the male reproductive tract, such as altered testicular descent. In adults, several studies showed an interaction between consumption of these drugs and the functioning of the male genital tract. In this context, it is essential to understand the mode of action of paracetamol and NSAIDs during fetal development as in adulthood. The abundant consumption of these drugs and the growing concerns about the evolution of human fertility are therefore a major public health problem.Our preliminary studies show that some of these NSAIDs affect the endocrine testicular capabilities, and can therefore be considered as endocrine disruptors. Moreover, in agreement with data obtained by the team in the rat, it seems that these drugs are involved in the metabolic cascade of arachidonic acid, itself involved in different metabolic pathways. The aim of the research program of this thesis is to examine the mechanisms of action of paracetamol and NSAIDs at exposures occurring during fetal life or adult.
Mechanism of action of paracetamol and non-steroidal anti-inflammatory drugs on the human testis
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