Multi-scale studies of Measeles virus nucleocapsid assembly

par Serafima Guseva

Projet de thèse en Biologie Structurale et Nanobiologie

Sous la direction de Rob W. H. Ruigrok et de Martin (PHYS) Blackledge.

Thèses en préparation à Grenoble Alpes , dans le cadre de Chimie et Sciences du Vivant , en partenariat avec Institut de Biologie Structurale (laboratoire) depuis le 02-03-2018 .


  • Résumé

    The project combines state-of-the-art expertise in solution NMR (partner 1), single molecule fluorescence imaging (partner 2), cryo-EM and structural virology (partners 3 and 4) as well as fluorescence spectroscopy (partners 1,2) to study the structure, dynamics and kinetics of nucleocapsid (NC) assembly in measles virus (MeV). The coordinator is recognised for his work using NMR to study the role of protein dynamics and flexibility in biological function, partners 2, 3 and 4 are renowned experts in single molecule imaging, EM and structural virology respectively. The aim of this project is to forge a new collaboration associating their separate expertise to establish a link between atomic and micron-scale structure and dynamics. We feel that this combination fulfils the stated goal of the GRAL Labex to ‘Provide structural information at different levels of resolution to help integrating structural and functional studies from single molecules to cellular organization.

  • Titre traduit

    Multi-scale studies of Measeles virus nucleocapsid assembly


  • Résumé

    The project combines state-of-the-art expertise in solution NMR (partner 1), single molecule fluorescence imaging (partner 2), cryo-EM and structural virology (partners 3 and 4) as well as fluorescence spectroscopy (partners 1,2) to study the structure, dynamics and kinetics of nucleocapsid (NC) assembly in measles virus (MeV). The coordinator is recognised for his work using NMR to study the role of protein dynamics and flexibility in biological function, partners 2, 3 and 4 are renowned experts in single molecule imaging, EM and structural virology respectively. The aim of this project is to forge a new collaboration associating their separate expertise to establish a link between atomic and micron-scale structure and dynamics. We feel that this combination fulfils the stated goal of the GRAL Labex to ‘Provide structural information at different levels of resolution to help integrating structural and functional studies from single molecules to cellular organization.