Expositions professionnelles aux solvants et vieillissement dans la cohorte CONSTANCES

par Noémie Letellier

Projet de thèse en Biologie Santé

Sous la direction de Claudine Berr.

Thèses en préparation à Montpellier , dans le cadre de Sciences Chimiques et Biologiques pour la Santé (Montpellier ; Ecole Doctorale ; 2015-....) , en partenariat avec Neuropsychiatrie : Recherche Epidémiologique et Clinique (laboratoire) et de Troubles cognitifs liés à l'âge (equipe de recherche) depuis le 15-12-2016 .


  • Résumé

    Significant cognitive deficits may be detectable long before the typical cognitive, behavioral, and social criteria of dementia are met. Besides cognition, physical function is a vital component of the functional status of older adults, and decline in physical functioning is inextricably linked to the aging process. There are clear parallels between age-related changes in cognitive and physical functioning. Besides acute toxicity observed during occupational life, research suggests long-term effects of chemical exposures for various chronic diseases, including cancer, pulmonary disease and neurodegenerative disorders, including dementia and Parkinson's disease. Our main objective is to study the mid- and long-term effects of occupational exposure to organic solvents, still massively use in occupational settings, on cognitive and physical functioning. Our motivation is that the effects of organic solvents on aging should be evaluated in the long term by considering the different components of occupational exposures: level and threshold, combination, exposure timing. Furthermore, arduous and difficult working conditions will be considered as potential confounding or mediating covariates in our main analysis. This study will be implemented in the frame of the CONSTANCES cohort, a randomly selected sample of French adults aged 18-69 years. The CONSTANCES study offers the opportunity to study the ageing process using various approaches and designs, a major condition for approaching complexity and interactions. A unique feature of CONSTANCES is the inclusion of a comprehensive set of cognitive and physical tests starting as young as 45 years, earlier in life than most of the available cohorts, and a complete retrospective assessment of occupational history and related exposures. Subjects are enrolled and examined in Health Screening Centers (HSC) for a comprehensive health examination: weight, height, blood pressure, electrocardiogram, vision, auditory, spirometry, and biological parameters; individuals aged 45 years and over undergo a cognitive, physical and functional check-up. This check-up is performed by a neuropsychologist and includes a series of neuropsychological tests exploring verbal episodic memory, verbal fluency , visuo-motor coordination, processing speed, concentration, mental flexibility and executive functions and a motor test battery ( gait speed, balance, hand grip test and finger tapping test). IADLs and associated questions on autonomy and capabilities will help to assess the functional status of the participants at baseline and over the follow-up. Assessment of occupational exposures is based on a questionnaire on lifelong and current occupational exposure to chemical agents administered by trained interviewers. We will further work on solvents exposure obtained after linkage to the MATGENE job-exposure matrices. Our analyses will be conducted on a sample of more than 40,000 subjects for whom data will be available in January 2017.

  • Titre traduit

    Occupational exposures to solvents and ageing in the CONSTANCES cohort


  • Résumé

    Significant cognitive deficits may be detectable long before the typical cognitive, behavioral, and social criteria of dementia are met. Besides cognition, physical function is a vital component of the functional status of older adults, and decline in physical functioning is inextricably linked to the aging process. There are clear parallels between age-related changes in cognitive and physical functioning. Besides acute toxicity observed during occupational life, research suggests long-term effects of chemical exposures for various chronic diseases, including cancer, pulmonary disease and neurodegenerative disorders, including dementia and Parkinson's disease. Our main objective is to study the mid- and long-term effects of occupational exposure to organic solvents, still massively use in occupational settings, on cognitive and physical functioning. Our motivation is that the effects of organic solvents on aging should be evaluated in the long term by considering the different components of occupational exposures: level and threshold, combination, exposure timing. Furthermore, arduous and difficult working conditions will be considered as potential confounding or mediating covariates in our main analysis. This study will be implemented in the frame of the CONSTANCES cohort, a randomly selected sample of French adults aged 18-69 years. The CONSTANCES study offers the opportunity to study the ageing process using various approaches and designs, a major condition for approaching complexity and interactions. A unique feature of CONSTANCES is the inclusion of a comprehensive set of cognitive and physical tests starting as young as 45 years, earlier in life than most of the available cohorts, and a complete retrospective assessment of occupational history and related exposures. Subjects are enrolled and examined in Health Screening Centers (HSC) for a comprehensive health examination: weight, height, blood pressure, electrocardiogram, vision, auditory, spirometry, and biological parameters; individuals aged 45 years and over undergo a cognitive, physical and functional check-up. This check-up is performed by a neuropsychologist and includes a series of neuropsychological tests exploring verbal episodic memory, verbal fluency , visuo-motor coordination, processing speed, concentration, mental flexibility and executive functions and a motor test battery ( gait speed, balance, hand grip test and finger tapping test). IADLs and associated questions on autonomy and capabilities will help to assess the functional status of the participants at baseline and over the follow-up. Assessment of occupational exposures is based on a questionnaire on lifelong and current occupational exposure to chemical agents administered by trained interviewers. We will further work on solvents exposure obtained after linkage to the MATGENE job-exposure matrices. Our analyses will be conducted on a sample of more than 40,000 subjects for whom data will be available in January 2017.