Organisation du pole cellulaire bactérien

par Ipek Altinoglu

Projet de thèse en Sciences de la vie et de la santé

Sous la direction de Frédéric Boccard et de Yoshiharu Yamaichi.

Thèses en préparation à Paris Saclay , dans le cadre de Structure et Dynamique des Systèmes Vivants , en partenariat avec Institut de Biologie Intégrative de la Cellule (I2BC) (laboratoire) et de Université Paris-Sud (établissement de préparation de la thèse) depuis le 01-10-2015 .

  • Titre traduit

    ORGANIZATION OF BACTERIAL CELL POLE


  • Résumé

    Cell poles in rod-shaped bacteria constitute key subcellular domains that are often critical for motility, chemotaxis, protein secretion, antibiotic resistance, and chromosome segregation. Previous work in the laboratory identified a protein called HubP which acts as polar anchor: it interacts with ParA1 chromosome partitioning protein to tether at cell pole thus involved in chromosome segregation. Furthermore they showed that HubP also interacts with proteins involved in chemotaxis and flagella biosynthesis. In my thesis project, I will try to understand the spatio-temporal organization of bacterial cell poles and its impact on various cellular functions, by identification and characterization of further polar proteins as well as microscopic analysis using super resolution microscopy