Etude en imagerie-génétique des asymétries des structures du lobe temporal : association de leurs caractéristiques propres à l'homme avec des données génétiques et épigénétiques.

par Yann Le Guen

Projet de thèse en Imagerie et physique médicale

Sous la direction de Vincent Frouin.

Thèses en préparation à Paris Saclay , dans le cadre de Electrical,Optical,Bio: PHYSICS_AND_ENGINEERING , en partenariat avec Unité d'analyse et de traitement de l'information (laboratoire) et de Université Paris-Sud (établissement de préparation de la thèse) depuis le 01-10-2015 .


  • Résumé

    The asymmetrical structure of the temporal lobe has already been demonstrated through several studies. This research path ranges from the study of the sulcal pits, Im et al , 2009, which shows an asymmetrical number of pits in the superior temporal sulcus (STs), to the study of the STs depth profile, Leroy et al, 2015, underlining a significant asymmetry which is observed in human brains but not in chimpanzees. Following these results, we are investigating the likely genetic influence on these structures. We use data available from the IMAGEN project among which 1765 individuals have been genotyped and undergone T1 scans. The phenotypes are extracted from the T1 images using processes included or derived from the ones available in the Brainvisa toolbox. In a first approach, we compute the variance accounted for by the SNPs (Single Nucleotide Polymorphisms) as a whole. Then, these results obtained on the IMAGEN cohort will be compared and eventually confirmed on data available from the Human Connectome Project (HCP), which has released data from twins and siblings allowing us to perform a pedigree study to estimate the variance accounted for by the genome for the phenotypes examined. Later on, we will select gene candidates available from BrainSpan: Atlas of the Developing Human Brain, to identify the causal SNPs which control the variations of the phenotypes considered.

  • Titre traduit

    An imaging-genetic study of the asymmetries in the temporal lobe structures: association of these human-specific markers of development with genetics and epigenetics.


  • Résumé

    The asymmetrical structure of the temporal lobe has already been demonstrated through several studies. This research path ranges from the study of the sulcal pits, Im et al , 2009, which shows an asymmetrical number of pits in the superior temporal sulcus (STs), to the study of the STs depth profile, Leroy et al, 2015, underlining a significant asymmetry which is observed in human brains but not in chimpanzees. Following these results, we are investigating the likely genetic influence on these structures. We use data available from the IMAGEN project among which 1765 individuals have been genotyped and undergone T1 scans. The phenotypes are extracted from the T1 images using processes included or derived from the ones available in the Brainvisa toolbox. In a first approach, we compute the variance accounted for by the SNPs (Single Nucleotide Polymorphisms) as a whole. Then, these results obtained on the IMAGEN cohort will be compared and eventually confirmed on data available from the Human Connectome Project (HCP), which has released data from twins and siblings allowing us to perform a pedigree study to estimate the variance accounted for by the genome for the phenotypes examined. Later on, we will select gene candidates available from BrainSpan: Atlas of the Developing Human Brain, to identify the causal SNPs which control the variations of the phenotypes considered.