Thèse de doctorat en Aspects moléculaires et cellulaires de la biologie
Soutenue en 2008
à Strasbourg 1 en cotutelle avec l'Université de Fudan - Shanghai - Chine .
Analyse moléculaire et caractérisation fonctionnelle des gènes codant des protéines de la famille de Nucléosome Assembly Protein 1 (NAP1) chez les plantes
Pas de résumé disponible.
Eukaryotic genomes are packaged into chromatin, a regularly repeated structure whose fundamental building block is the nucleosome. Each nucleosome core particle is composed of a histone octamer consisting of two molecules each of the core histones H2A, H2B, H3, and H4, around which approximately 146–147 bp of DNA is wrapped. The assembly of nucleosome is the first step of chromatin assembly which is important for the chromatin structure affecting a broad ranges of biological events including DNA replication, repair, recombination, transcription, cell differentiation, proliferation, and organism development, and is fulfilled with the help of histone chaperones, which are important for the organization and dynamics of chromatin templates, and are involved in the storage, translocation to the nucleus and exchange of histones and their deposition onto the DNA for replication-dependent chromatin assembly. [. . . ].