Applicateur ultrasonore interstitiel pour l'ablation des cancers du foie, et destruction de thrombus par ondes de choc extracorporelles associées à un thrombolytique encapsulé

par Cédric Goldenstedt

Thèse de doctorat en Génie biologique

Sous la direction de Dominique Cathignol.

Soutenue en 2008

à Lyon 1 .


  • Pas de résumé disponible.

  • Titre traduit

    Ultrasound interstital applicator for liver cancer ablation, and thrombus disruption using extracorporeal shockwaves combined with encapsulated thrombolytic


  • Résumé

    1st part: an interstitial ultrasound applicator was designed for treating large size liver tumours. In an in vivo study on pig, the applicator was inserted in the hepatic parenchyma under echographic guidance to produce lesions. The performances of the applicator were estimated in such conditions and the therapeutic interest was discussed. In the 2nd part, extracorporeal shockwaves were used for destroying particles containing a drug, and for disrupting blood clots. Among the microparticles tested in vitro, gelatine-based capsules can be broken up by shockwaves through cavitation related mechanisms. This type of particle might be used for local drug delivery. Extracorporeal shockwaves are able to rapidly disrupt in vitro blood clots. Moreover, additional use of a lytic agent makes the shockwaves more efficient to disrupt the clots. Encapsulating of a thombolytic agent (streptokinase) might allow coupling these two techniques

Consulter en bibliothèque

La version de soutenance existe sous forme papier

Informations

  • Détails : 1 vol. (137 f.)
  • Annexes : Bibliogr. f. 131-136

Où se trouve cette thèse ?

  • Bibliothèque : Université Claude Bernard (Villeurbanne, Rhône). Service commun de la documentation. BU Sciences.
  • Disponible pour le PEB
  • Cote : T50/210/2008/68bis
Voir dans le Sudoc, catalogue collectif des bibliothèques de l'enseignement supérieur et de la recherche.