Thèse de doctorat en Génie biologique
Sous la direction de Dominique Cathignol.
Soutenue en 2008
à Lyon 1 .
Ultrasound interstital applicator for liver cancer ablation, and thrombus disruption using extracorporeal shockwaves combined with encapsulated thrombolytic
1st part: an interstitial ultrasound applicator was designed for treating large size liver tumours. In an in vivo study on pig, the applicator was inserted in the hepatic parenchyma under echographic guidance to produce lesions. The performances of the applicator were estimated in such conditions and the therapeutic interest was discussed. In the 2nd part, extracorporeal shockwaves were used for destroying particles containing a drug, and for disrupting blood clots. Among the microparticles tested in vitro, gelatine-based capsules can be broken up by shockwaves through cavitation related mechanisms. This type of particle might be used for local drug delivery. Extracorporeal shockwaves are able to rapidly disrupt in vitro blood clots. Moreover, additional use of a lytic agent makes the shockwaves more efficient to disrupt the clots. Encapsulating of a thombolytic agent (streptokinase) might allow coupling these two techniques