Thèse de doctorat en Sciences de la vie et de la santé
Sous la direction de Pierre Bonnet.
Soutenue en 2005
à Tours .
Pas de résumé disponible.
Effects of chronic hypoxia and carbon monoxide on cardiac function and potassium channels in rat coronary artery smooth muscle cells
This work shows that low doses of carbon monoxyde (CO) corresponding to air pollution impair right ventricle (RV) and right coronary circulation adaptive response in animals preexposed to hypoxic hypoxemia. A complementary study on coronary smooth muscle cell shows that voltage-gated potassium channels contribute to the repolarizing outward membrane currents and they were impaired following hypoxemia and CO exposures. This work provides physiological findings on the cardiac effects of air pollution and increased sensitivity in hypoxic hypoxemic animals. We have used the techniques of cardiovascular functional exploration and electrophysiological assessment of the coronary smooth muscle cell.