Thèse de doctorat en Biologie - Sciences - Santé
Sous la direction de Ahmad Oulmouden.
Soutenue en 2004
à Limoges , en partenariat avec Université de Limoges. Faculté des sciences et techniques (autre partenaire) .
Coat color genetic in cattle : contribution to the study of the tyrosinase gene family
These works belong to the research thematic related to the identification of specific molecular markers for each French cattle breeds. They consist in the study of the tyrosinase family genes and of the RAB38 gene. The cloning and the polymorphism study of the coding region of TYR, TYRP1, DCT, RAB38 genes show a very good conservation at the genomic and proteic levels with other species. No racial polymorphism correlated to a phenotype has been detected. However, the transcriptional study shows that highly variable expression levels could explain the coat color differences. Notably, a lack in TYRP1 expression seems to be characteristic of the e/e animals at the EXTENSION locus. These works also confirm the epistatic property of the SILVER allele specific to the Charolaise breed