Thèse de doctorat en Sciences médicales.Toxicologie
Sous la direction de Robert Molimard.
Soutenue en 1989
à Paris 11 .
Régulation par les fumeurs de la quantité de fumée aspirée en fonction de la teneur en nicotine de la cigarette.
Pharmalogical factors of tobacco dependence
To better understand the tobacco dependence mechanism, the influence of pharmaco-logical factors, and the relative effect of nicotine among smoke components, two kinds of experiments were done. I- In 94 smokers, physiological measurements before and after smoking a cigarette from their own brand has shown that : - biological concentrations of tobacco products are not related to cigarette yields; - alveolar carbon monoxide level is not related to the smoke pH (6. 45-7. 55). II- Behavioral and psychomotor indexes obtained while smoking cigarettes of different composition showed that : - smokers submitted to a pharmacological deficit when smoking a cigarette free from active components increased their smoke intake and cigarette combustion of their next cigarette. While smoking a cigarette free from active components but enriched with nicotine, subjects reduced their smoke intake and increased the smoke intake from their next normal cigarette; - subjects smoking a low nicotine cigarette regulated their smoking behavior by increasing smoke intake from the next cigarette only. While smoking a high nicotine cigarette they compensated immediatly. These results show that smokers are able to regulate the amount of nicotine intake by their smoking behavior but that others pharmacological factors seems to be looked for by smokers.